Information disclosure

2021/01/08

On January 8, 2021, Pingshan Center held its first employee report meeting, and established a report evaluation leadership group to participate in the entire report meeting. The members of the leadership group include Chen Jie'an, Assistant Director and Minister of Chemistry of Pingshan Center, Yin Feng, Minister of Biology, Tang Hongmei, Minister of Comprehensive Department, and Fu Qingqing, Human Resources Supervisor. 30 employees from three departments, adhering to the principle of seeking truth from facts, reported on their work performance, experiences, difficulties encountered, existing problems, and work plans and goals for the next year in 2020.

2021/01/05

On the afternoon of January 5, 2021, the first board of directors of the Pingshan Biomedical R&D and Transformation Center (hereinafter referred to as the "Pingshan Center") of Shenzhen Bay Laboratory was established and held its first meeting. The meeting elected the first governing body of Pingshan Center. Chairman: Wu Yundong, academician of the CAS Member, executive deputy director of Shenzhen Bay Laboratory; Vice Chairman: Chen Huaping, deputy district chief of Pingshan District; Tu Huan, deputy director of Shenzhen Bay Laboratory; members of the board: Sun Yongkui, academician of the National Academy of Engineering; Huang Ming, director of Pingshan District Science and Technology Innovation Bureau; Li Zigang, executive director of Pingshan Center; Huang Yong, director of Shenzhen Bay Laboratory's Beipu Joint Research Center. The establishment of the council will further clarify the construction plan, organizational structure, institutional system, spatial platform and other matters of the Pingshan Center, and promote its better and faster development. In 2020, Pingshan Center actively promoted the integration of industry, academia, and research, promoting the transformation of achievements. Cooperated with Shenzhen Technology University, Shenzhen Third People's Hospital, IFlytek, Xinhe Biology, China Resources Sanjiu, Bangtai Hesheng, Jianyuan Medicine and other university research institutes, medical institutions, biomedical enterprises and institutions, and established a total of 7 projects; The Chemical biology platform and Medicinal chemistry platform were initially constructed, and the preliminary research on the public service platform was completed; Apply for 22 invention patents and 3 PCT patents. In 2021, Pingshan Center will be committed to accelerating the transformation and technological upgrading of Pingshan biopharmaceutical achievements. Develop 8-10 core technologies for building small molecule and peptide drugs; Establish a comprehensive scientific database and a scientific literature library; Promote the construction of academician workstations and cultivate scientific and technological innovation teams; Actively expanding cooperation and exchange with biopharmaceutical enterprises, medical institutions, and university research institutes in national, provincial, municipal, and Pingshan areas, or providing technical support and public services; Conduct research on regional biopharmaceutical related enterprises and actively promote the incubation of technology enterprises; Establish an asset management and service company, and build a technology transformation investment and financing platform. In addition, the Pingshan Biopharmaceutical R&D and Transformation Center of Shenzhen Bay Laboratory will establish a high-level project evaluation mechanism, further focus on the transformation field, and actively promote the construction of incubators. We will also actively strive to establish a public service platform for biopharmaceuticals in Shenzhen, providing systematic, convenient, efficient, and open services to higher education institutions, scientific research institutions, biopharmaceutical enterprises, government departments, and the public within the Pingshan District Biopharmaceutical Innovation Industrial Park, becoming an important supporting force for promoting the development of the national level biopharmaceutical industry base in Pingshan District. Related background: Shenzhen Bay Laboratory is a Guangdong Provincial Laboratory jointly established by the Municipal Science and Technology Innovation Commission and the Shenzhen Graduate School of Peking University, which was constructed by our city. As one of the research institutions directly under the Shenzhen Bay Laboratory, the Pingshan Biopharmaceutical R&D and Transformation Center of Shenzhen Bay Laboratory undertakes the industrial transformation function. It will build 2 new drug R&D platforms, 2 pharmaceutical transformation platforms, and 4 public service platforms, and carry out research cooperation with prestigious universities such as Princeton University to promote the industrial transformation of basic research achievements of Shenzhen Bay Laboratory. It will become an important achievement display base for Shenzhen Bay Laboratory, serving as the

2020/12/31

2020年12月31日，深圳湾实验室党委书记胡晓军率队对高科创新中心、坪山生物医药研发转化中心开展“元旦”节前安全巡查。 　　   　　胡晓军书记一行先后对高科创新实验区域、办公区域、坪山生物医药研发转化中心实验区域等进行实地安全巡查，了解“元旦”前各项安全措施落实情况，并与员工进行亲近的访谈。 　　   　　胡晓军书记强调，一是各研究所/中心、部门在“元旦”前要切实落实好各项安全措施，重点关注化学试剂、消防、用电等方面安全，在假期前要清理废弃纸箱等可燃物质，关闭非必要连续供电的电源;二是要加大安全检查力度，及时发现并消除安全隐患;三是要做好节假日期间人员值班安排，增加节假日期间巡查频次。他表示，过去的一年，在全体员工共同努力下，深圳湾实验室取得一定成绩，在来年发展也将会更加辉煌。走访过程中，他向员工致以节日问候和新春祝福。 　　   　　深圳湾实验室综合部、平台部等有关人员陪同巡查。 　　撰稿 | 平台部 吴帅 　　摄影 | 姬 二 　　编辑 | 鍮 鍮On December 31, 2020, Hu Xiaojun, Secretary of the Party Committee of Shenzhen Bay Laboratory, led a team to conduct a pre New Year's Day safety inspection of the High Tech Innovation Center and Pingshan Biomedical Research and Development Transformation Center. Secretary Hu Xiaojun and his delegation conducted on-site safety inspections on the high-tech innovation experimental area, office area, and Pingshan Biomedical Research and Transformation Center experimental area, to understand the implementation of various safety measures before the New Year's Day, and conducted close interviews with employees. Secretary Hu Xiaojun emphasized that firstly, all research institutes/centers and departments should effectively implement various safety measures before the "New Year's Day", focusing on the safety of chemical reagents, fire protection, electricity, and other aspects. Before the holiday, combustible materials such as discarded cardboard boxes should be cleaned up, and unnecessary continuous power supply should be turned off; Secondly, we need to increase the intensity of safety inspections, promptly identify and eliminate safety hazards; Thirdly, it is necessary to arrange personnel on duty during holidays and increase the frequency of inspections during holidays. He stated that in the past year, with the joint efforts of all employees, Shenzhen Bay Laboratory has achieved certain results, and its development will be even more brilliant in the coming year. During the visit, he extended holiday greetings and New Year greetings to the employees. Personnel from the Comprehensive Department and Platform Department of Shenzhen Bay Laboratory accompanied the inspection. Author | Wu Shuai from the Platform Department Photography | Ji Er Edit | B and B

2020/12/30

Introduction Recently, the Pingshan Biomedical R&D and Transformation Center of Shenzhen Bay Laboratory collaborated with the Shenzhen Graduate School of Peking University to publish a research paper titled "Substrate-binding stabilizes the hydrodynamic cluster to understand the inhibition of bacterial ubiquitin ligase IpaH9.8" in the sub journal "Communications Biology" of Nature, This article introduces the new progress made in the study of the activation mechanism of bacterial E3 enzymes. This study focuses on the Shigella E3 enzyme IpaH9.8, and elucidates the mechanism of IpaH9.8 self inhibition and substrate induced activation by analyzing the crystal structure of the full length protein of IpaH9.8 and its complex with substrate protein hGBP1. (Long press to recognize the QR code in the picture below to read the paper) Recently, the Pingshan Biomedical R&D and Transformation Center of Shenzhen Bay Laboratory collaborated with the Shenzhen Graduate School of Peking University to publish a research paper titled "Substrate-binding stabilizes the hydrodynamic cluster to understand the inhibition of bacterial ubiquitin ligase IpaH9.8" in the sub journal "Communications Biology" of Nature, This article introduces the new progress made in the study of the activation mechanism of bacterial E3 enzymes. This study focuses on the Shigella E3 enzyme IpaH9.8, and elucidates the mechanism of IpaH9.8 self inhibition and substrate induced activation by analyzing the crystal structure of the full length protein of IpaH9.8 and its complex with substrate protein hGBP1. IpaH family proteins are E3 Ubiquitin ligase from Gram-negative bacteria, which are composed of three parts: the N-terminal T3SS signal sequence, the LRR domain responsible for binding the substrate, and the C-terminal conserved NEL domain with E3 enzyme function. These E3 enzymes can inhibit host inflammation and endogenous immune response by hijacking the host's ubiquitin Proteasome signaling pathway, thus promoting the infection process. In host cells, in order to avoid self ubiquitination and degradation by the host's ubiquitin system, or to avoid the production of free Ub chains that activate the host immune response, IpaH proteins are usually in a self inhibitory state when there is no substrate. IpaH9.8 is an E3 enzyme secreted by Shigella, which can target ubiquitination to degrade NEMO (NF) in host cells- κ B regulator), GBP1 (Guanylate-binding protein 1) and other proteins, which in turn affect the immune response of the host. In this study,

2020/12/24

12月24日下午，坪山中心与深圳技术大学药学院在国富文化广场14楼签署了合作备忘录。备忘录从两方面制定了双方今后一段时期的合作内容：第一，建立人才交流合作平台，大力推进本科生、研究生、博士后联合培养工作，广泛利用已建立的国际化学术和人才交流网络，加强技术、人才对接与互补，加强国际化复合型人才培养与交流;第二，建立长效创新合作机制，定期举办年度研讨会，学术研讨会、创新专题论坛等活动，联合承担各级各类科技攻关项目，加强创新链、产业链、金融链有机融合，推动科技成果转移转化。 　　     　　备忘录签署之前，深圳技术大学药学院院长贺震旦教授带领团队成员参观了坪山中心生物实验室和化学实验室，随后双方核心团队成员进行了一次交流座谈会。在会上，贺院长介绍了药学院成立的背景、首届招生，以及计划的平台建设和专业设置等情况。坪山中心执行主任李子刚教授表示全力支持药学院的创建，将在仪器平台建设和人才队伍建设等方面提供帮助。 　　     　　坪山中心与深圳技术大学药学院有着天然的合作基础。双方都坐落于坪山，互为近邻，研究方向存在一致性，未来有很多方向可以开展合作，通过发挥各自优势，积极组织，整合资源，打造富有活力的以创新驱动为核心竞争力的智创平台，共同完善创新医疗技术的区域生态链，促使坪山区生物医药产业的发展更上一层楼。 　　     　　图片|陈龙剑 　　文字|陈龙剑 　　编辑|陈龙剑 　　出品|PTMC文化创意工作室On the afternoon of December 24, Pingshan Center and the School of Pharmacy of Shenzhen Technology University signed a memorandum of cooperation at the 14th floor of Guofu Cultural Plaza. The memorandum sets out the cooperation content for the two sides in the future from two aspects: firstly, establish a talent exchange and cooperation platform, vigorously promote the joint training of undergraduate, graduate, and postdoctoral students, widely utilize the established international chemistry and talent exchange network, strengthen technology and talent docking and complementarity, and strengthen the cultivation and exchange of international composite talents; Second, establish a long-term innovation cooperation mechanism, regularly hold annual seminars, Academic conference, innovation forums and other activities, jointly undertake various scientific and technological research projects at all levels, strengthen the organic integration of innovation chain, industrial chain and financial chain, and promote the transfer and transformation of scientific and technological achievements. Before signing the memorandum, Professor He Zhendan, Dean of the School of Pharmacy of Shenzhen Technology University, led the team members to visit the Pingshan Central Biological Laboratory and Chemical Laboratory, and then the core team members of both sides held an exchange forum. At the meeting, Dean He introduced the background of the establishment of the School of Pharmacy, the first enrollment, as well as the planned platform construction and professional settings. Professor Li Zigang, Executive Director of Pingshan Center, expressed full support for the establishment of the School of Pharmacy and will provide assistance in the construction of instrument platforms and talent teams. Pingshan Center has a natural cooperation foundation with the School of Pharmacy of Shenzhen Technology University. Both sides are located in Pingshan, adjacent to each other, and there is consistency in their research directions. In the future, there are many directions for cooperation. By leveraging their respective advantages, actively organizing, integrating resources, and creating a vibrant innovation driven intelligent innovation platform, we can jointly improve the regional ecological chain of innovative medical technology, and promote the development of the biopharmaceutical industry in Pingshan District to a higher level. Picture | Chen Longjian Text | Chen Longjian Editor | Chen Longjian Production | PTMC Cultural and Creative Studio

2020/12/04

On December 4th, the 2020 Biopharmaceutical R&D and Clinical Transformation Forum was held on the 14th floor of Pingshan Biopharmaceutical R&D and Transformation Center (hereinafter referred to as "Pingshan Center") at Shenzhen Bay Laboratory keyword

2020/11/22

11月22日，坪山区委书记陶永欣，区长李勇，科技创新局局长黄鸣，城投公司董事长高晓兵等到坪山高新区产学研基地考察调研。 　　陶书记此行的目的主要是考察基地展厅提升进度，实地查勘综合楼宿舍的选址，查勘学生活动操场的规划等;并与入驻项目代表进行会谈，了解入驻项目的进展，以及入驻项目对基地配套方面的诉求。 　　紧促的行程之中，陶书记一行抽出宝贵的时间，考察了坪山中心，并和坪山中心执行主任李子刚教授亲切会谈，李教授向陶书记汇报了坪山中心的发展现状和长远规划，陶书记对深圳湾实验室生物医药转化项目选择坪山表示赞许，认为生物医药行业选择坪山就是选择了未来，坪山区政府出台了促进生物医药产业集聚发展的相关扶持政策，在坪山可以享受大湾区深港合作的创新政策优势。陶书记对坪山中心项目的进度表示满意，并对坪山中心的未来充满期望。 　　         　　出品 | PTMC文化创意工作室On November 22nd, Tao Yongxin, Secretary of the Pingshan District Party Committee, Li Yong, District Mayor, Huang Ming, Director of the Science and Technology Innovation Bureau, and Gao Xiaobing, Chairman of the Urban Investment Company, visited the Pingshan High tech Zone's industry university research base for investigation and research. The main purpose of Tao Shuji's trip is to inspect the progress of improving the exhibition hall of the base, conduct on-site inspections of the location of the dormitory in the comprehensive building, and survey the planning of the student activity playground; And hold meetings with representatives of the settled projects to understand the progress of the settled projects and the demands of the settled projects on the supporting facilities of the base. During the tight schedule, Tao Shuji and his team took valuable time to inspect the Pingshan Center and had a friendly meeting with Professor Li Zigang, the Executive Director of the Pingshan Center. Professor Li reported to Secretary Tao on the development status and long-term plan of the Pingshan Center. Tao Shuji praised the selection of Pingshan for the Shenzhen Bay Laboratory Biopharmaceutical Conversion Project and believed that the biopharmaceutical industry chose Pingshan for the future, The Pingshan District Government has introduced relevant support policies to promote the agglomeration and development of the biopharmaceutical industry, and can enjoy the innovative policy advantages of Shenzhen Hong Kong cooperation in the Greater Bay Area in Pingshan. Tao Shuji expressed satisfaction with the progress of the Pingshan Center project and full of expectations for the future of the Pingshan Center. Production | PTMC Cultural and Creative Studio

2020/11/18

健康元药业集团股份有限公司集团成立于1992年，历经数十年奋斗，现已成为国内大型综合性药业集团，旗下拥有太太药业、丽珠医药、海滨制药、健康药业、山东健康等众多知名医药企业。产品涵盖处方药、OTC及保健品三大领域，已成功推出太太口服液、静心口服液、鹰牌花旗参、丽珠得乐、丽珠肠乐、意可贴、丽珠威、倍能等知名品牌，并以出色的疗效和卓越的品质赢得消费者一致推崇。 　　   　　11月18日，健康元药业集团股份有限公司高层领导莅临坪山中心参观考察，坪山中心主任涂欢携执行主任李子刚等有关人员亲切接待了来访嘉宾，并进行了真诚友好的会谈。 　　   　　坪山中心主任助理陈杰安首先介绍了深圳湾实验室和坪山中心的建设目标、组织架构、国际合作、建设规划及技术优势等情况。会上双方探讨了生物医药全产业链前沿趋势，并就打通生物医药项目、产品、专业人才、资本、技术、信息等各类资源对接通道，促进各类生物科技创新资源高效、精准对接展开了交流。随后，健康元一行参观了坪山中心化学实验室和生物实验室。 　　   　　近一个月来，陆续有行业专家、知名企事业单位负责人及有关领导到访坪山中心。坪山中心已经用自己的技术和人才及制度优势，吸引到行业有关人士的高度关注。 　　出品 / PTMC文化创意工作室Jiankangyuan Pharmaceutical Group Co., Ltd. Corporate group was founded in 1992. After decades of struggle, it has become a large comprehensive pharmaceutical group in China. It has many well-known pharmaceutical enterprises such as Madame Pharmaceutical, Lizhu Pharmaceutical, Haibin Pharmaceutical, Health Pharmaceutical, Shandong Health, etc. Our products cover three major fields: prescription drugs, OTC, and health products. We have successfully launched well-known brands such as Madame Oral Liquid, Jingxin Oral Liquid, Eagle Brand Ginseng, Lizhu Deli, Lizhu Changle, Yike Tie, Lizhu Wei, and Beineng, and have won unanimous praise from consumers for their excellent efficacy and quality. On November 18th, senior leaders of Jiankangyuan Pharmaceutical Group Co., Ltd. visited Pingshan Center for inspection. Director Tu Huan and Executive Director Li Zigang of Pingshan Center warmly received the visiting guests and had sincere and friendly talks. Chen Jie'an, Assistant Director of Pingshan Center, first introduced the construction goals, organizational structure, international cooperation, construction planning, and technical advantages of Shenzhen Bay Laboratory and Pingshan Center. At the meeting, both parties discussed the cutting-edge trends in the entire biopharmaceutical industry chain and exchanged ideas on opening up channels for the docking of various resources such as biopharmaceutical projects, products, professional talents, capital, technology, and information, and promoting efficient and precise docking of various biotech innovation resources. Subsequently, Jian Kangyuan and his delegation visited the chemical and biological laboratories of Pingshan Center. In the past month, industry experts, heads of well-known enterprises and institutions, and relevant leaders have successively visited Pingshan Center. The Pingshan Center has attracted high attention from industry insiders with its technological, talent, and institutional advantages. Production/PTMC Cultural and Creative Studio

2020/11/11

The south is like fire, and the dangui is fragrant. On November 11, Hu Xiaojun, Secretary of the Party Committee, led more than 11 young scientists and functional departments of the laboratory to visit Pingshan District, and had in-depth discussions with Tao Yongxin, Secretary of the Pingshan District Party Committee, Li Yong, District Mayor and other main responsible comrades, investigated the construction of the laboratory Pingshan Biomedical R&D and Transformation Center, and visited local universities and representative enterprises to carry out extensive exchanges on scientific research project cooperation. Relevant personnel of the Organization Department of the Pingshan District Party Committee and the District Talent Work Bureau accompanied the inspection.