Research trends-Shenzhen Bay Laboratory Pingshan Biopharmaceutical R&D and Transformation Center

2022/08/11

Research Trends | Li Zigang/Yin Feng's Research Group Achieves New Research Progress in the Field of Targeted Protein Degradation

Recently, the Pingshan Center/Peking University Shenzhen Graduate School Li Zigang/Yin Feng research group published a research paper titled "Targeting UBE2C for degradation by bioPROTACs based on bacterial E3 ligase" in the journal "Chinese chemical letters", reporting a bioPROTAC that can specifically target UBE2C and its related biological activity validation.

2022/07/20

Overview of Research Trends of Pingshan Center from April to June

Overview of research trends at Pingshan Center from April to June.

2022/07/08

Li Zigang/Yin Feng's research group has made significant progress in the "group transfer" strategy based on matte salt molecules

Recently, the Li Zigang/Yin Feng research group of Pingshan Center published a research paper in the flagship journal of the Chinese Chemical Society, CCS Chemistry. In this paper, a group transfer strategy based on sulfonium salt molecules was developed for site selective modification of target protein Cysteine (Cys) through ligand directed chemistry.

2022/06/30

Scientific research trends | Li Zigang/Yin Feng's research group has made new research progress on Histidine proteome of breast cancer cells

Recently, the research team led by Li Zigang and Yin Feng from Pingshan Center/Peking University Shenzhen Graduate School published a research paper titled "Histidine Specific bioconjugation via visible light promoted proteomic activation" in the internationally renowned journal "Chemical Science", reporting a novel visible light catalyzed His chemical modification method and its chemical proteomics application.

2022/06/10

β The therapeutic potential of amyloid protein surface inhibitors: only oligomers formed by secondary nucleation can disrupt the integrity of liposome membranes

On June 10th, the Li Zigang | Yin Feng research group at Pingshan Center and Professor John Viles from Queen Mary College London collaborated to publish an article in The FEBS Journal.

2022/05/05

Research Trends | Pingshan Center has synthesized a new generation of chiral bifunctional NHC catalysts

Huang Yong/Chen Jiean's research group further expanded the scope of bonding by using the nitrogen heterocyclic carbene thiourea bifunctional catalyst and realized the first highly enantioselective selenium Michael addition reaction.

2022/05/05

Research Trends | Pingshan Center Proposes a New Method to Improve the Performance of Transistor Biosensors

The research team led by Li Zigang/Yin Feng from Pingshan Center and Associate Professor Zhang Min from Peking University published an article in the internationally renowned journal Carbon, elaborating on a biosensor based on carbon nanotube thin film transistors for high sensitivity detection of unlabeled DNA.

2022/03/05

Scientific research trends | Pingshan Center has developed a new probe of propargyl sulfonium salt to target and label cysteine proteome in living cells

2022/03/01

Research Trends | Pingshan Center Achieves High Selective Target Labeling and Drug Release Using Novel Stable Disulfide Bonds

Recently, the Li Zigang/Yin Feng research group of Pingshan Biomedical Transformation Center at Shenzhen Bay Laboratory published a research paper titled "Chemo selective Cys Pen disability for proximity-induced cyclosteine cross linking" in ACS Chemical Biology magazine. This paper describes a cross-linking strategy that uses Cys Pen disulfide bonds to proximity induce cysteine targeting. This new strategy is designed to target disease related proteins