Research trends-Shenzhen Bay Laboratory Pingshan Biopharmaceutical R&D and Transformation Center

2022/02/17

$Scientific research trends | Pingshan Center's development of visible light proton coupled Electron transfer (PCET) induced large steric inertia Csp3-Csp3 fracture and its new functionalization strategy$

Scientific research trends | Pingshan Center's development of visible light proton coupled Electron transfer (PCET) induced large steric inertia Csp3-Csp3 fracture and its new functionalization strategy

Recently, the Huang Yong/Chen Jiean research group published an article online in Cell Reports Physical Science titled "Catalytical clearance and functionalization of bulk and inert Csp3 – Csp3 bonds via a delayed proton coupled electron transfer strategy"

2022/02/15

Scientific Research Trends | "Click chemistry Initiated by Matte Salt" Cycloaddition of Acetylene Matte Salt and Azide

On February 14, 2022, the Li Zigang | Yin Feng research group of Pingshan Center collaborated with Professor Zhang Xinhao of Shenzhen Bay Laboratory to publish an article titled "Sulfonium Triggered Alkyne Azide Click Cyclization" in the magazine "Organic Letters".

2022/01/07

Research Trends | Pingshan Center Achieves Important Research Progress in Developing Novel Peptide Inhibitors for Deubiquitinase USP30

On the same day, the Li Zigang/Yin Feng research group at Pingshan Center collaborated with Xu Naihan from Tsinghua International Graduate School to publish a research paper titled "Identification of an automobile, mitophagy inducing peptide derived from the transmembrane domain of USP30" in the internationally renowned journal "Autophagy" (IF=16.016)

2022/01/05

Scientific Research Trends | Pingshan Center has made research progress in the development of peptide conjugated drugs (PDCs) against COVID-19

Recently, Li Zigang/Yin Feng of Pingshan Center and Zhou Yaoqi of Shenzhen Bay Laboratory jointly developed a new type of polypeptide drug conjugates (PDCs) targeting COVID-19 (SARS-CoV-2) Papain like protease (PLpro) protein, and their achievements were published in the Journal of Medical Chemistry, a journal of Medicinal chemistry

2021/12/31

Scientific Research Trends | Pingshan Center Developing New Methods for Amination Promotion of Sulfate Salts in Aqueous Phase

Li Zigang, the research group of Chemical biology and Biotechnology of Peking University Shenzhen Graduate School and Pingshan Biomedical R&D and Transformation Center of Shenzhen Bay Laboratory, published a paper entitled "Electronic Sulfonium Promoted Peptide and Protein Enhancement in Aqueous Media" on the magazine Organic Letters.

2021/11/16

Research Trends | Li Zigang/Yin Feng's Research Group and Peking University Team Collaborate to Achieve New Breakthroughs in the Field of Biosensors

Recently, Professor Li Zigang/Researcher Yin Feng from the Pingshan Biomedical Transformation Center of Shenzhen Bay Laboratory and Associate Professor Zhang Min from Peking University collaborated to publish an article in the internationally renowned journal Biosensors and Bioelectronics in the field of biosensors. They constructed a new type of biosensor based on DNA folding technology and all carbon nanotube thin film transistors, and studied the application of this sensor in DNA detection of blood circulation tumors.

2021/09/23

Research progress has been made in the development of peptide based nuclide conjugated drugs through cooperation between Shenzhen Bay Laboratory Pingshan Center and Japan's National Institute of Measurement and Research

Recently, Li Zigang's research group published a report on Acta Pharmaceutica Sinica B, a Medicinal chemistry journal (Chinese name: Journal of Pharmacy, the leading journal of excellent action plan of Chinese scientific and technological journals, IF=11.413),

2021/09/17

Research Trends | Pingshan Center and Bayer Pharmaceuticals Targeting HIF1 α Research progress in the development of peptide inhibitors for p300 interactions

Zi Gang/Yin Feng's research group published the journal of Medicinal chemistry entitled "Potential invasion of HIF1 α And p300 interaction by a constrained perspective derived from CITED2 "research paper. This study uses the helix induced stable peptide method of terminal Aspartic acid,

2021/09/17

Scientific Research Trends | Huang Yong/Chen Jie'an Research Group Development of N-heterocyclic carbene mediated four component free radical tandem Coupling reaction

Recently, the Huang Yong/Chen Jiean research group published a research article titled "An N-Heterocyclic carbon catalysed four component reaction: chemoselective critical critical relay coupling involving the homoisolate intermediate" in ACS Catalog.