Dr. Yin Feng

Director of the Biological Department of Pingshan Biopharmaceutical R&D and Transformation Center at Shenzhen Bay Laboratory
Mailbox：yinfeng@szbl.ac.cn

Yin Feng

Director of the Biology Department of Pingshan Biomedical R&D and Transformation Center

Email: yinfeng@szbl.ac.cn

Research group homepage: https://yin.szptmc.cn/

Education and work experience

2019.12-present: Shenzhen Bay Laboratory, Pingshan Biomedical R&D and Transformation Center, Researcher, Director of Biology Department

2018.08-2018.10: Visiting scholar, Hong Kong University of Science and Technology

2017.11-2019.11: Associate Researcher, Shenzhen Graduate School, Peking University

2015.10-2017.10: Postdoctoral Fellow, Shenzhen Graduate School, Peking University

2014.04-2015.09: Postdoctoral Fellow, Nanomedicine, Nanyang Technological University, Singapore

2009.09-2014.07: Ph.D., Cell Biology, Peking University

2005.09-2009.07: Bachelor of Biotechnology, School of Life Sciences, South China University of Technology

Awards and honors

100 postdoctoral innovators in Guangdong Province

Guangdong Province science and technology innovation young top-notch talents

Shenzhen overseas high-level talents

Leading talents in Nanshan District, Shenzhen

Supported by the "Outstanding Postdoctoral Fellow" Fund of Peking University Tsinghua Joint Center for Life Sciences

Publish articles

As the first author and co-first author:

1. Kuan Hu#,Feng Yin#, Ziyuan Zhou, ChenshanLian, Yinghuan Liu, Chengjie Sun, Wenjun Li, Jianing Zhang and Zigang Li* “Directional assembly of a stapled α-helical peptide ”. Chemical Communications. 2019, 55(70): 10484-10487. (Co-first author；IF：6.52)

2. Xuewen He#, Feng Yin#, Dongyuan Wang, Ling-Hong Xiong, Ryan T. K. Kwok,PengFeiGao, Zheng Zhao, Jacky W. Y. Lam, Ken-Tye Yong, Zigang Li, Ben Zhong Tang.AIE Featured Inorganic-Organic Core@Shell Nanoparticle for High-Efficiency SiRNA Delivering and Real-Time Monitoring. Nanoletter. 2019,19: 2272-2279. (Co-first author；IF：12.08)

3. Feng Yin, Tommy Anderson, NishthaPanwar, Kang Zhang, SweeChuanTjin, Beng Koon Ng, Ho Sup Yoon, JunleQu, and Ken-Tye Yong. Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy.Nanotheranostics. 2018, 2(4): 371-386. (First author)

4. Kuan Hu#, Feng Yin#, Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, MingshengXie, Yuanzhi Lao, Wei Liang and Zi-gang Li. In-tether chiral center induced helical peptide modulators target p53-MDM2/MDMX and inhibit tumor growth in stem-like cancer cell. Theranostics. 2017,13;7(18):4566-4576. (Co-first author；IF：11.55)

5. Feng Yin, BoboGu, Yining Lin, Nishtha Panwar, Swee Chuan Tjin, Junle Qu, Shu Ping Lau, Ken-Tye Yong. Functionalized 2D nanomaterials for gene delivery applications. Coordination Chemistry Reviews. 2017, 347: 77-97. (First author；IF：13.324)

6. Feng Yin, Kuan Hu, Si Chen, Dongyuan Wang, Jianing Zhang, MingshengXie, Dan Yang, MengQiu, Han Zhang and Zi-gang Li. Black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells. J. Mater. Chem. B. 2017, 5: 5433-5440. (First author；IF：4.726)

7. Feng Yin, Kuan Hu, Yangzi Chen, Mengying Yu, Dongyuan Wang, Ken-Tye Yong, Fei Lu, Yongye Liang, and Zigang Li. SiRNA Delivery with PEGylatedGraphene Oxide Nanosheets for Combined Photothermal and Gene Therapy for Pancreatic Cancer. Theranostics. 2017,7(5):1133-1148. (First author；IF：11.55)

8. Feng Yin, NishthaPanwar, Danny Jian Hang Tng, SweeChuanTjin, Kuan Wang and Ken-Tye Yong.The application of mesoporous silica nanoparticle family in cancer theranostics. Coordination Chemistry Reviews. 2016,319:86-109. (First author；IF：13.324)

9. Feng Yin, Chengbin Yang, Qianqian Wang, ShuwenZeng, Rui Hu, Guimiao Lin, JinglinTian, SiyiHu, RongFengLan, Ho Sup Yoon, Fei Lu,Kuan Wang, and Ken-Tye Yong. A Light-Driven Therapy of Pancreatic AdenocarcinomaUsing Gold Nanorods-Based Nanocarriers forCo-Delivery of Doxorubicin and siRNA. Theranostics. 2015, 5(8): 818-833. (First author；IF：11.55)

10. Feng Yin, Butian Zhang, ShuwenZeng, Guimiao Lin, JinglinTian, Chengbin Yang, Kuan Wang, GaixiaXu, and Ken-Tye Yong. Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo. J Mater Chem B Mater Biol Med. 2015,3:6081. (First author；IF：4.726)

11. Feng Yin, RongfengLan, Xiaoming Zhang, Linyu Zhu, Fangfang Chen, ZhengshuangXu, Yuqing Liu, Tao Ye, Hong Sun, Fei Lu and Hui Zhang. LSD1 regulates pluripotencyof embryonic stem/carcinoma cells through HDAC1-mediated deacetylation of histoneH4 at lysine 16. Mol. Cell. Biol. 2014, 34(2): 158–179. (First author；IF：5.032)

As the co-corresponding author:

1. Na Liu, Dongyuan Wang, ChenshanLian, Rongtong Zhao, LichengTu, Yichi Zhang, Jianbo Liu, Huilin Zhu, Mengying Yu, Chuan Wan, Di Li, Shuiming Li, Feng Yin* and Zigang Li* “Selective Covalent Targeting of Anti‐Apoptotic BFL‐1 by a Sulfonium Tethered Peptide”. ChemBioChem. 2021, 22: 340 –344. (Co-Corresponding author, IF:3.16)

2. Yang Li, ChenshanLian, ZhanfengHou, Dongyuan Wang, Rui Wang, Chuan Wan, WanjinZhong, Rongtong Zhao, Yuena Wang, Shuiming Li, Feng Yin* and Zigang Li* “Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation”. ChemicalCommunications. 2020, 56: 3741-3744. (Co-Corresponding author, IF:6.52)

3. ZhanfengHou, Dong-Yuan Wang, Yang Li, Rongtong Zhao, Chuan Wan, Yue Ma, ChenshanLian, Feng Yin* and Zigang Li*”A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification” J. Org. Chem., 2020,85(3): 1698-1705. (Co-Corresponding author, IF:4.72)

4. Wenjun Li, YuboGao, Jiaona Zhang, Xiaofang Wang, Feng Yin*,Zigang Li*, Min Zhang* “Universal DNA detection realized by peptide based carbon nanotube biosensors ” Nanoscale Adv., 2020, 2: 717-723. (Co-Corresponding author)

5. Fadeng Yang, Wan Zhang, Yixiang Jiang, Feng Yin*, Wei Han* and Zigang Li* “Targeting the amyloid-β fibril surface by constrained helical peptide inhibitor”. Biochemistry. 2020, 59(3): 290-296. (Co-Corresponding author, IF:3.37)

6. Yixiang Jiang, Xuehan Jiang, Xiaodong Shi, Fadeng Yang, Yang Cao, Xuan Qin, ZhanfengHou, MingshengXie, Na Liu, Qi Fang, Feng Yin*, Wei Han*, Zigang Li* “α-helical motif as inhibitors of toxic amyloid-β oligomer generation via highly specific recognition of amyloid surface” iScience. 2019, 17: 87-100. (Co-Corresponding author)

7. Jianing Zhang, Yue Ma, Kuan Hu, Yuan Feng, Si Chen, Xiaoyang Yang, Jacky Fong-Chuen Loo, Han Zhang, Feng Yin* and Zigang Li* “Surface Coordination of Black Phosphorus with Modified Cisplatin”. Bioconjugate Chemistry. 2019, 30(6): 1658-1664. (Co-Corresponding author, IF:4.77)

8. Wang Dongyuan, Yu Mengying, Liu Na, LianChenshan, HouZhanfeng, Wang Rui, Zhao Rongtong, Li Wenjun, Jiang Yixiang, Shi Xiaodong, Li Shuiming, FengYin*,ZigangLi*. A sulfonium tethered peptide ligand rapidly and selectively modifies protein cysteine in vicinity. Chemical Science. 2019, 10(19): 4966-4972. (Co-Corresponding author, IF:9.06)

9. Dongyuan Wang, Wenjun Li, Rongtong Zhao, Longjian Chen, Na Liu, Yuan Tian, Hui Zhao, MingshengXie, Fei Lu, Qi Fang, Wei Liang*, Feng Yin*, Zigang Li*. Stabilized peptide HDAC inhibitors derived from HDAC1 substrate H3K56 for the treatment of cancer stem-like cells in vivo. Cancer Research. 2019, 79(8): 1769-1783. (Co-Corresponding author, IF: 12.70)

10. Yue Ma, Wenjun Li, Ziyuan Zhou, Xuan Qin, Dongyuan Wang, YuboGao, Zhiqiang Yu, Feng Yin*, and Zigang Li*. “Peptide-AptamerCoassemblyNanocarrier for Cancer Therapy” Bioconjugate Chem., 2019, 30(3): 536-540. (Co-Corresponding author, IF: 4.54)

11. Na Liu, Rongtong Zhao, YueMaa, Dongyuan Wang, Chen Yan, Dongxian Zhou, Feng Yin* and Zigang Li*. The Development of Epigenetics and Related Inhibitors for Targeted Drug Design in Cancer Therapy. Current Topics in Medicinal Chemistry. 2018, 18(28): 2380 – 2394. (Co-Corresponding author, IF: 3.24)

12. Zhanfeng Hou, Chengjie Sun, Hao Geng, Kuan Hu, Mingsheng Xie, Yue Ma, Fan Jiang,* Feng Yin,* and Zigang Li* “Facile Chemoselective Modiﬁcation of Thio-Ethers Generates Chiral Center-Induced Helical Peptides ” Bioconjugate Chemistry. 2018. 29(9): 2904-2908. (Co-Corresponding author, IF: 4.485)

13. Xiaodong Shi, Rongtong Zhao, Yixiang Jiang, Hui Zhao, Yuan Tian, Yanhong Jiang, Jingxu Li, Weirong Qin, Feng Yin* and Zigang Li*. Reversible Stapling of Unprotected Peptides viaChemoselective Methionine Bis-alkylation/Dealkylation.Chemical Science. 2018.9:3227-32. (Corresponding author；IF：8.668； Q1)

14. Wenjun Li, Kuan Hu, Qingzhou Zhang, Dongyuan Wang, Yue Ma, ZhanfengHou, Feng Yin*, and Zigang Li. N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties. Chemistry Communication. 2018,54: 1865-8.v(Corresponding author；IF：6.319)

15. Li Wenjun, Wang Dongyuan, Shi Xiaodong, Li Jingxu, Yue Ma, Wang Yanding, Li Tingting, Zhang Jianing, Zhao Rongtong, Yu Zhiqiang, FengYin*and ZigangLi*. A siRNA-induced peptide co-assembly system as a peptide-based siRNAnanocarrier for cancer therapy. Materials Horizons. 2018, 5(4): 745-752. (Co-Corresponding author; IF: 13.05)

16. Jingxu Li, Kuan Hu, Hailing Chen, YuJie Wu, Longjian Chen, Feng Yin,* Yuan Tian,* and Zigang Li. In-tether chiral center modulates the proapoptotic activity of KLApeptide. Chemistry Communication. 2017, 53: 10452-5. (Corresponding author；IF：6.319)