Dr. Li Zigang

Executive Director of Pingshan Biopharmaceutical R&D and Transformation Center at Shenzhen Bay Laboratory
Mailbox：lizg@pkusz.edu.cn

Li Zigang

Executive Director of Pingshan Biomedical R&D and Transformation Center

Phone: +86-755-2603-3616

Email: lizg@pkusz.edu.cn

Research group homepage: http://web.pkusz.edu.cn/li

Education and work experience

2009-2010 Postdoctoral
Fellow, Department of Chemistry and Chemical Biology, Harvard University, 2004-2008 Ph.D., Department of Chemistry, University of Chicago, 2001-2004 M.S.
, Department of Chemistry, Tulane University, 1996-2001 University of Science and Technology of China, Department of Neuroscience and Biophysics

Awards and honors

2017 Bayer Scholar Award

2016 Guangdong Special Branch Plan <> million project leading talents

2013 Shenzhen Outstanding Youth Fund Award

2012 Shenzhen Overseas High-level Talents

2010 Distinguished researcher of "Hundred Talents Program" of Peking University

2010 National Cancer Center Postdoctoral Fellowship

2008 Harper Thesis Award, University of Chicago

Representative outcomes
1. Dan, Y. et. al. “Development of a high quantum yield dye for tumor imaging” Chemical Science 2017 (Accepted)
1. Yin, F.; Hu, K.; Chen Y.; Yu, M.; Wang, D.; Wang, Q.; Yong, K. T.; Lu, F.; Liang, Y.; Li, Z. “SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer” Theranostics. 2017, 7, 1133.
1. Zheng, W.; Cai, X.; Xie, M.; Liang, Y.; Wang, T.; Li, Z. “Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus” Cell Chemical Biology 2016, 23, 1002.
1. Zhao, H.; Liu, Q. S.; Geng, H.; Tian, Y.; Cheng, M.; Jiang, Y. H.; Xie, M. S.; Niu, X. G.; Jiang, F.; Zhang, Y. O.; Lao, Y. Z.; Wu, Y. D.; Xu, N. H.; Li, Z. “Crosslinked Aspartic Acids as Helix-Nucleating Templates” Angew. Chem. Int. Ed. 2016, 55, 12088.
1. Yuan, F.; Deng, Y. Y.; Zhou, W. Y.; Zhang, M.; Li, Z. “A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field-effect transistors” Nano Research 2016, 9, 1701.
1. Tian, Y.; Li, J. X.; Zhao, H.; Zeng, X. Z.; Wang, D. Y.; Liu, Q. S.; Niu, X. G.; Huang, X. H.; Xu, N. H.; Li, Z. “Stapling of unprotected helical peptides via photoinduced intramolecular thiol-yne hydrothiolation” Chemical Science 2016*, 7*, 3325.
1. Hu, K.; Geng, H.; Zhang, Q.; Liu, Q.; Xie, M.; Sun, C.; Li, W.; Lin, H.; Jiang, F.; Wang, T.; Wu, Y. D.; Li, Z. “An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide” Angew. Chem. Int. Ed. 2016, 55, 8013.
1. Zhang, Q. Z.; Jiang, F.; Zhao, B. C.; Lin, H. C.; Tian, Y.; Xie, M. S.; Bai, G. Y.; Gilbert, A. M.; Goetz, G. H.; Liras, S.; Mathiowetz, A. A.; Price, D. A.; Song, K.; Tu, M. H.; Wu, Y. J.; Wang, T.; Flanagan, M. E.; Wu, Y. D.; Li, Z. G. “Chiral Sulfoxide-Induced Single Turn Peptide alpha-Helicity” Scientific Reports 2016, 6, 38573.
1. Zhao, W.; Qian, H.; Li, Z.; Sun, J. “Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium-Ring Lactams” Angew. Chem. Int. Ed. 2015, 54, 10005.
1. Zhao, W.; Li, Z.; Sun. J. “A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition” J. Am. Chem. Soc. 2013, 135, 4680.
1. Cai, S.; Zhao, X.; Wang, X.; Liu, Q.; Li, Z.; Wang, D. Z.; “Visible-light-promoted C-C bond cleavage: photocatalytic generation of iminium ions and amino radicals” Angew. Chem. Int. Ed. 2012, 51, 8050.
1. Yang, S. D.; Li, Z.; Han, X.; He, C. “Platinum (II)-Catalyzed Intramolecular Cyclization of o-Substituted Aryl Alkynes through sp(3) C-H Activation” Angew. Chem. Int. Ed. 2009, 48, 3999.
1. Li, Z.; Brouwer, C; He, C. “Gold-catalyzed organic transformations” Chemical Reviews 2008, 108, 3239.
1. Chen, H.; Hu, J.; Chen, P. R.; Lan, L. F.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C. “The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism” Proc. Natl. Acad. Sci. 2008, 105, 13586.
1. Chang, S.; Bray, S.M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T. “Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila” Nature Chemical Biology 2008, 4, 256.
1. Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Gold(III)-catalyzed nitrene insertion into aromatic and benzylic C-H groups” J. Am. Chem. Soc. 2007, 129, 12058.
1. Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Silver-catalyzed intermolecular amination of C-H groups” Angew. Chem. Int. Ed. 2007, 46, 5184.

Dr. Li Zigang

Education and work experience

Awards and honors

Representative outcomes