Scientific research

Li Zigang

 

 

Li Zigang

 

Executive Director of Pingshan Biomedical R&D and Transformation Center

Phone: +86-755-2603-3616

Email: lizg@pkusz.edu.cn

Research group homepage: http://web.pkusz.edu.cn/li

 

 

  • Education and work experience

    2009-2010 Postdoctoral
    Fellow, Department of Chemistry and Chemical Biology, Harvard University, 2004-2008 Ph.D., Department of Chemistry, University of Chicago, 2001-2004 M.S.

    , Department of Chemistry, Tulane University, 1996-2001 University of Science and Technology of China, Department of Neuroscience and Biophysics

 

  • Awards and honors

    2017 Bayer Scholar Award

    2016 Guangdong Special Branch Plan <> million project leading talents

    2013 Shenzhen Outstanding Youth Fund Award

    2012 Shenzhen Overseas High-level Talents

    2010 Distinguished researcher of "Hundred Talents Program" of Peking University

    2010 National Cancer Center Postdoctoral Fellowship

    2008 Harper Thesis Award, University of Chicago

 

  • Representative outcomes

    1. Dan, Y. et. al. “Development of a high quantum yield dye for tumor imaging” Chemical Science 2017 (Accepted)
    1. Yin, F.; Hu, K.; Chen Y.; Yu, M.; Wang, D.; Wang, Q.; Yong, K. T.; Lu, F.; Liang, Y.; Li, Z. “SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer” Theranostics. 2017, 7, 1133.
    1. Zheng, W.; Cai, X.; Xie, M.; Liang, Y.; Wang, T.; Li, Z. “Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus” Cell Chemical Biology 2016, 23, 1002.
    1. Zhao, H.; Liu, Q. S.; Geng, H.; Tian, Y.; Cheng, M.; Jiang, Y. H.; Xie, M. S.; Niu, X. G.; Jiang, F.; Zhang, Y. O.; Lao, Y. Z.; Wu, Y. D.; Xu, N. H.; Li, Z. “Crosslinked Aspartic Acids as Helix-Nucleating Templates” Angew. Chem. Int. Ed. 2016, 55, 12088.
    1. Yuan, F.; Deng, Y. Y.; Zhou, W. Y.; Zhang, M.; Li, Z. “A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field-effect transistors” Nano Research 2016, 9, 1701.
    1. Tian, Y.; Li, J. X.; Zhao, H.; Zeng, X. Z.; Wang, D. Y.; Liu, Q. S.; Niu, X. G.; Huang, X. H.; Xu, N. H.; Li, Z. “Stapling of unprotected helical peptides via photoinduced intramolecular thiol-yne hydrothiolation” Chemical Science 2016*, 7*, 3325.
    1. Hu, K.; Geng, H.; Zhang, Q.; Liu, Q.; Xie, M.; Sun, C.; Li, W.; Lin, H.; Jiang, F.; Wang, T.; Wu, Y. D.; Li, Z. “An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide” Angew. Chem. Int. Ed. 2016, 55, 8013.
    1. Zhang, Q. Z.; Jiang, F.; Zhao, B. C.; Lin, H. C.; Tian, Y.; Xie, M. S.; Bai, G. Y.; Gilbert, A. M.; Goetz, G. H.; Liras, S.; Mathiowetz, A. A.; Price, D. A.; Song, K.; Tu, M. H.; Wu, Y. J.; Wang, T.; Flanagan, M. E.; Wu, Y. D.; Li, Z. G. “Chiral Sulfoxide-Induced Single Turn Peptide alpha-Helicity” Scientific Reports 2016, 6, 38573.
    1. Zhao, W.; Qian, H.; Li, Z.; Sun, J. “Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium-Ring Lactams” Angew. Chem. Int. Ed. 2015, 54, 10005.
    1. Zhao, W.; Li, Z.; Sun. J. “A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition” J. Am. Chem. Soc. 2013, 135, 4680.
    1. Cai, S.; Zhao, X.; Wang, X.; Liu, Q.; Li, Z.; Wang, D. Z.; “Visible-light-promoted C-C bond cleavage: photocatalytic generation of iminium ions and amino radicals” Angew. Chem. Int. Ed. 2012, 51, 8050.
    1. Yang, S. D.; Li, Z.; Han, X.; He, C. “Platinum (II)-Catalyzed Intramolecular Cyclization of o-Substituted Aryl Alkynes through sp(3) C-H Activation” Angew. Chem. Int. Ed. 2009, 48, 3999.
    1. Li, Z.; Brouwer, C; He, C. “Gold-catalyzed organic transformations” Chemical Reviews 2008, 108, 3239.
    1. Chen, H.; Hu, J.; Chen, P. R.; Lan, L. F.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C. “The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism” Proc. Natl. Acad. Sci. 2008, 105, 13586.
    1. Chang, S.; Bray, S.M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T. “Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila” Nature Chemical Biology 2008, 4, 256.
    1. Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Gold(III)-catalyzed nitrene insertion into aromatic and benzylic C-H groups” J. Am. Chem. Soc. 2007, 129, 12058.
    1. Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Silver-catalyzed intermolecular amination of C-H groups” Angew. Chem. Int. Ed. 2007, 46, 5184.
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