Laboratory

The research group proposed a new strategy for proton-shuttling catalysis (spatial regulation of protons) and realized a series of highly asymmetric reactions, and then designed multi-site catalytic intermediates to participate in selective protonation (multi-site catalytic species, the time regulation of protons), unlocks a series of unknown chemical reactions. Based on this, the concept of selective proton migration is applied to the migration reactions of other groups, providing new ideas and technical means for the synthesis of important drug fragments and skeletons. The main research directions include:

(1) the development of proton migration reagents;

(2) the study of multi-site reactive intermediates;

(3) the study of group migration reactions;

(4) the application of synthetic methodologies to targeted anti-tumor drugs Chemical research.